Debugging

FFXVI has a rudimentary anti-debugging mechanism (in non-denuvo versions). IsDebuggerPresent() is present on the entrypoint and will immediately return if a debugger is attached.

Another anti-debug mechanism is used after the splash screen (which may involve HeapFlags detection - needs more research).

x64dbg

ScyllaHide's Hide from PEB -> BeingDebugged and HeapFlags is enough to hide the debugger.

Cheat Engine

Use the VEH debugger. Settings -> Debugger Options -> Use VEH debugger. This also works on Denuvo protected versions of the game.